DNA-binding,antioxidant activity and solid-state fluorescence studies of copper(II), zinc(II) and nickel(II) complexes with a Schiff base derived from 2-oxo-quinoline-3-carbaldehyde |
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| Authors: | Zeng-Chen Liu Zheng-Yin Yang Tian-Rong Li Bao-Dui Wang Yong Li Ming-Fang Wang |
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| Affiliation: | (1) College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, People’s Republic of China;(2) Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, 730000 Lanzhou, People’s Republic of China; |
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| Abstract: | A Schiff base derived from 2-oxo-quinoline-3-carbaldehyde-4-aminophenazone and its Cu(II), Zn(II) and Ni(II) complexes were synthesized. The molecular structures of the Zn(II) and Ni(II) complexes were determined by X-ray crystal diffraction. The DNA-binding modes of the compounds were investigated by spectroscopic methods, viscosity measurements and ethidium bromide-DNA displacement experiments. The experimental evidence indicated the compounds interact with calf thymus DNA through intercalation. Additionally, the compounds exhibited potential antioxidant properties in in vitro studies, and the Cu(II) complex was the most effective. The solid-state fluorescence properties of the Zn(II) complex were studied. |
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