Debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane |
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| Authors: | A I Kalashnikov S V Sysolyatin G V Sakovich I A Surmacheva V N Surmachev and Yu T Lapina |
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| Abstract: | The debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetra-cyclo5.5.0.03,11.05,9]dodecane by catalytic hydrogenolysis in a mixture of HCOOH with other RCOOH (R = Me, Et, Pri) is accompanied by the N-formylation of the liberated secondary amino groups. The alkaline hydrolysis of the obtained products makes it possible to
remove the formyl groups with the retention of the acetyl groups. |
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