The reaction of optically active α-aminocarboxylic acid hydrazides with triethyl orthoesters |
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| Authors: | Agnieszka Kudelko Wojciech ZielińskiKrzysztof Ejsmont |
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| Institution: | a Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Krzywoustego 4, PL-44100 Gliwice, Poland
b Faculty of Chemistry, Opole University, Oleska 48, Opole, Poland |
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| Abstract: | New derivatives of 2-(1-amino-1-phenylmethyl)-1,3,4-oxadiazole and 1,2,4-triazin-6-one were synthesised in the reactions of optically active α-aminocarboxylic acid hydrazides and triethyl orthoesters in xylene. The electronic and steric effects of substituents at the α position influencing the formation of five- or six-membered products are discussed. |
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| Keywords: | α-Aminocarboxylic acid hydrazide Synthesis Racemisation 2-Aminomethyl-1 3 4-oxadiazole 1 2 4-Triazin-6-one Lanthanide shift reagent pKa Ionisation constant |
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