DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside |
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| Authors: | Gören Ahmet C Zhou Bing-Nan Topçu Gülaçti Kökdil Gamze Kingston David G I |
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| Institution: | TUBITAK, Ulusal Metroloji Enstitüsü, Group of Chemistry, PO Box 54, 41470, Gebze-Kocaeli, Turkey. ahmet.goren@ume.tubitak.gov.tr |
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| Abstract: | An iridoid glucoside reptoside (1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds (24S)-24-ethylcholesta-5,25-dien-3beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data. |
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