An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid |
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Authors: | Pradeep B Patil Jayavant D Patil Suyog N Korade Siddheshwar D Kshirsagar Sanjay P Govindwar Dattaprasad M Pore |
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Institution: | 1.Department of Chemistry,Shivaji University,Kolhapur,India;2.Department of Bio-Chemistry,Shivaji University,Kolhapur,India |
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Abstract: | Acidic ionic liquid, (Py)2SO]HSO4]2 has been used as an efficient catalyst for the reaction of ketone with thiosemicarbazide in ethanol at room temperature for the eco-friendly synthesis of spiro-1,2,4-triazolidine-3-thiones. Smooth reactions, ambient temperature, use of alcohol as a solvent, high yields, easy work-up procedure and excellent recyclability of ionic liquid and high atom economy are the auxiliary advantages of the present protocol, which makes it ecofriendly. All the synthesized 1,2,4-trioazoles were screened for antimicrobial activity. Most of compounds displayed moderate to good biological activity. |
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