One-pot syntheses of 2,6-diiododiaryl ethers from <Emphasis Type="Italic">para</Emphasis>-EWG-substituted phenols by diacetoxyiodobenzene |
| |
Authors: | De-Jun Zhou Shu-Qiang Yin Yun-Chang Fan Qiang Wang |
| |
Institution: | 1.School of Physics and Chemistry,Henan Polytechnic University,Jiaozuo,China;2.Faculty of Pharmaceutical Sciences,University of Toyama,Toyama,Japan |
| |
Abstract: | 2,6-Diiododiaryl ethers are not only useful blocks to construct substituted diaryl ethers but are also characteristic drug precursors. In this research, a one-pot tandem oxidation of phenols substituted with electron-withdrawing group at the para position by excess diacetoxyiodobenzene is proven as a novel and efficient method for preparing 2,6-diiododiaryl ethers. Using this method, three new 2,6-diiododiaryl ethers, namely, methyl 3,5-diiodo-2-methoxy-4-phenoxybenzoate (2), methyl 3,5-diiodo-4-phenoxybenzoate (6), and 1-(2,6-diiodo-4-nitrophenoxy)benzene (7) were readily obtained from the corresponding phenols, and the yields were good. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|