An investigation of the bromination of 1,4-dihydropyridine rings |
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| Authors: | Ori RorlikZeev Tashma Claudia M Barzilay Morris Srebnik |
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| Institution: | a Institute of Drug Research, School of Pharmacy, Hebrew University in Jerusalem, Jerusalem 99120, Israel
b Bargal Analytical Instruments, Air Port City 70100, Israel |
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| Abstract: | Conditions for bromination at the C3 and C5 positions of a 1,4-dihydropyridine (DHP) were investigated. The effect of base concentration, base type, reaction temperature, and solvent were examined. DHP derivatives with ester and amide moieties were synthesized and brominated. The bromine atoms can be replaced by other substituents, utilizing Suzuki cross coupling. |
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