Microwave-assisted synthesis of derivatives of khellinone under phase-transfer catalytic conditions |
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| Authors: | El?bieta Hejchman Dorota Maciejewska and Irena Wolska |
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| Institution: | (1) Department of Physics, VMKV Engineering College, Vinayaka Mission University, Salem, Tamilnadu, 636 308, India;(2) Department of Chemistry, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal;(3) World Class University (WCU) Program of Chemical Convergence for Energy and Environment (C2E2), School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, 151-744, Korea;(4) Department of Industrial Chemistry and Materials Engineering, University of Messina, C/da di Dio Vill. S. Agata, 98166 Messina, Italy |
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| Abstract: | The microwave-assisted synthesis of four new 5-acetyl-4,7-dimethoxy-6-hydroxybenzofuran (khellinone) analogs is described.
The structures of the obtained derivatives in the solid state are evaluated on the basis of 13C CP/MAS NMR spectra and theoretical calculations at DFT level. A single crystal X-ray diffraction structure is presented
for 8-acetyl-7-hydroxy-4-methylcoumarin. 1,4-Bis(5-acetyl-4,7-dimethoxybenzofuran-6-yloxy)butane was evaluated for potential
anticancer activity in an in vitro screening panel of 60 human tumor cell lines. Selected leukemia, non-small cell lung cancer, CNS, melanoma, ovarian, and
breast cancer cell lines were sensitive to this compound. |
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