An efficient silane-promoted nickel-catalyzed amination of aryl and heteroaryl chlorides |
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Authors: | Manolikakes Georg Gavryushin Andrei Knochel Paul |
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Institution: | Department Chemie und Biochemie, Ludwig-Maximilians-Universit?t, Butenandtstrasse 5-13, 81377 Munich, Germany. |
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Abstract: | A new silane-promoted nickel-catalyzed amination of aryl chlorides with 0.5 mol % of Ni(acac)2, 1 mol % of 3,5,6,8-tetrabromo-1,10-phenanthroline, and polymethylhydrosiloxane was developed. A broad range of aryl and heteroaryl chlorides can be coupled with secondary amines and anilines to give the desired (het)arylamines in good to excellent yields. The reaction is sensitive to the nature and amount of the silane promoter. |
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