Solid-phase synthesis of n,n-disubstituted s,n'-diarylisothioureas: facile exchange reactions of isocyanates |
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| Authors: | Katritzky Alan R Vvedensky Vladimir Rogovoy Boris V Kovalenko Katherine Torres Eduardo Forood Behrouz |
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| Affiliation: | Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu |
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| Abstract: | Reactions of resin-bound 1,1-disubstituted-2-arylisothioureas 4aa',ab'-ec' with aryl isocyanates, diversely substituted at the para and/or meta positions, and with o-fluoro- and 2,4-difluorophenyl isocyanate followed by appropriate cleavage led to the formation of N,N-disubstituted S,N'-diarylisothioureas 9[1-70] in good yields and high purities. |
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