Membrane assembly driven by a biomimetic coupling reaction |
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Authors: | Budin Itay Devaraj Neal K |
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Affiliation: | Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA. |
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Abstract: | One of the major goals of synthetic biology is the development of non-natural cellular systems. In this work, we describe a catalytic biomimetic coupling reaction capable of driving the de novo self-assembly of phospholipid membranes. Our system features a coppercatalyzed azide-alkyne cycloaddition that results in the formation of a triazole-containing phospholipid analogue. Concomitant assembly of membranes occurs spontaneously, not requiring preexisting membranes to house catalysts or precursors. The substitution of efficient synthetic reactions for key biochemical processes may offer a general route toward synthetic biological systems. |
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