On the Synthesis and Reactions of Indole-2-carboxylic Acid Hydrazide |
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Authors: | Abd El-Wareth A O Sarhan |
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Institution: | (1) Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt, EG |
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Abstract: | Summary. Indole-2-carboxylic acid hydrazide was prepared and allowed to react with aromatic aldehydes in acidic medium to give the
corresponding hydrazone derivatives in good yields. The hydrazones were cyclized to indolo2,3-d]pyridazine derivatives by refluxing with acetyl chloride. The indole carbohydrazide was converted to 2-triazolylindoles which
acted as starting materials for several indole derivatives. A number of new indole derivatives were also prepared and structurally
confirmed.
Received October 17, 2000. Accepted (revised) December 12, 2000 |
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Keywords: | , ,Indole alkaloids, Synthesis, Hydrazides, Indolopyridazines, Indolyltriazoles, |
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