Synthesis of Organofluoro Compounds Using Methyl Perfluoroalk‐2‐ynoates as Building Blocks |
| |
| Authors: | Jie Chen Hui Zhang Weiguo Cao |
| |
| Institution: | 1. Department of Chemistry, Innovative Drug Research Center Shanghai University, Shanghai, P. R. China;2. Laboratory for Microstructures, Instrumental Analysis and Research Center of Shanghai University, Shanghai, P. R. China;3. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, P. R. China;4. Key Laboratory of Synthetic Organic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, P. R. China;5. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, P. R. China |
| |
| Abstract: | This review provides an overview of several synthetic applications of methyl perfluoroalk‐2‐ynoates, leading to convenient preparation of many perfluoroalkylated compounds. The use of these important substrates in the synthesis of various five‐, six‐, and seven‐membered heterocycles, cyclopentadienes, and biphenyls is described, alongside a discussion of the mechanistic aspects of these reactions. |
| |
| Keywords: | drug design fluorine Michael addition perfluoroalkyl groups synthetic methods |
|
|
