A concise total synthesis of DL-histrionicotoxin |
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| Authors: | Karatholuvhu Maheswaran S Sinclair Alex Newton Annabella F Alcaraz Marie-Lyne Stockman Robert A Fuchs Philip L |
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| Institution: | School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom. |
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| Abstract: | The synthesis of (+/-)-histrionicotoxin has been achieved in just nine steps using a two-directional synthesis strategy. Key reactions include a two-directional cross-metathesis, a tandem oxime formation/Michael addition/1,4-prototopic shift/3 + 2]-cycloaddition cascade, a selective Z,Z-bisenyne formation, and a one-pot N-O and bischloroacetylene reduction. |
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