99mTc-Labeled human and camel lactoferrin for detection of Staphylococcus aureus infections |
| |
| Authors: | Alifa Kanoun Issam B. Salem Frida Darghouth Amine Asmi Halima El Hatmi Isabelle ADT Mouldi Saidi |
| |
| Affiliation: | 1.Research Unit, Application of Nuclear Techniques in the Fields of Health, Agriculture and Environment,National Centre for Nuclear Science and Technology (CNSTN),Ariana,Tunisia;2.Corporation of Pharmaceutical Industry Ibn Al Baytar,La Soukra,Tunisia;3.Faculty of Sciences of Bizerte,Zarzouna,Tunisia;4.Laboratoire Elevage et faune Sauvage,Institut des Régions Arides,Medenine,Tunisia;5.ISARA Lyon, BioDyMIA (Bioingénierie et Dynamique Microbienne aux Interfaces Alimentaires),Univ Lyon, Université Claude Bernard Lyon 1,Bourg en Bresse,France |
| |
| Abstract: | Human and camel lactoferrin, were labeled with technetium-99m using a simple technique that yielded a labelling efficiency of 98% and stable complexes over time. The camel Lactoferrin was purified. The proteins were investigated for targeting infections in experimental animals. The biodistribution of those labeled proteins in mice infected with Staphylococcus aureus at the femoral muscle was investigated and test ratios of 3.43 and 3.71 were obtained after 60 min for the camel and the human Lactoferrin, respectively. These values were compared to each other and to those reported in the literature, leading us to conclude that the radiotracers are efficient. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
