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Evaluation of infection imaging potential of |
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| Authors: | Ayça Tunçel Kasim Ocakoglu Suleyman Gokhan Colak Osman Yılmaz İsmail Öztürk Fatma Yurt |
| Affiliation: | 1.Department of Nuclear Applications, Institute of Nuclear Science,Ege University,Bornova, Izmir,Turkey;2.Advanced Technology Research & Application Center,Mersin University,Yenisehir, Mersin,Turkey;3.Department of Energy Systems Engineering, Faculty of Technology,Mersin University,Tarsus, Mersin,Turkey;4.Department of Animal Research Center,Dokuz Eylul University,Izmir,Turkey;5.Department of Pharmaceutical Microbiology, Faculty of Pharmacy,Ege University,Bornova, Izmir,Turkey |
| Abstract: | Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with 131I with high efficiency. In vitro uptake experiments of 131I-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. 131I-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that 131I-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection. |
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