Quantification
of amorphous content in maltitol by |
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Authors: | Minna Lappalainen Ilkka Pitkänen |
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Institution: | 1. Department of Chemistry, University of Jyv?skyl?, Jyv?skyl?, Finland, 35, 40014
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Abstract: | A
method was developed for the quantification of low levels of amorphous content
in maltitol with StepScan DSC. The method was based on the fact that the change
of specific heat at the glass transition is linearly proportional to the amorphous
content. The influence of different measurement parameters of StepScan DSC
was evaluated and two different calibration heating rates were tested. Synthetic
mixtures with various proportions of crystalline and amorphous maltitol were
prepared. Two different measurement methods were compared and the linear regression
between ΔCp
and amorphous content was obtained. The limit of detection (LOD) and the limit
of quantification (LOQ) values were for the fictive temperature 0.24% (amorphous
content) and 0.81% and for the half point temperature 0.27 and 0.92%, respectively,
(method 1) and for the fictive temperature 0.18 (amorphous content) and 0.61%
and for the half point temperature 0.16 and 0.52%, respectively (method 2).
Very low determination limits for the quantification of amorphous content
could be attained with the StepScan DSC method. However, the realistic limit
of quantification was somewhat higher (about 3%) because of noise in the StepScan
measurement. The main advantage of the StepScan DSC method for quantification
of amorphous content was that the glass transition and relaxation peaks are
separated into different curves and the interpretation becomes easier. |
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Keywords: | amorphous content maltitol StepScan DSC |
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