Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein |
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| Authors: | Furuta Takumi Sakai Minatsu Hayashi Hiroyasu Asakawa Tomohiro Kataoka Fumi Fujii Satoshi Suzuki Takashi Suzuki Yasuo Tanaka Kiyoshi Fishkin Nathan Nakanishi Koji |
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| Institution: | Department of Synthetic Organic and Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp |
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| Abstract: | An artificial phospholipid, possessing saturated alkyl chains as a membrane anchor and protein recognition site as well as an Fe(III)-EDTA moiety as a protein cleavable polar head group, was designed and synthesized based on the amidite method for the purpose of examination of cleavage of integral membrane proteins. |
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