Alternative products in one-pot reaction of benzylidenemalononitrile,N-methyl-2-thiocarbamoylacetamide,and ω-bromoacetophenone

N-Methyl-2-benzoylmethylsulfanyl-4-phenylnicotinamide and N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-acetamide have been obtained as alternative products to the desired N-methyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxamide by a one-pot cyclocondensation of benzylidenemalononitrile, N-methyl-2-thiocarbamoylacetamide, piperidine, and ω-bromoacetophenone. 2-Amino-1-methyl-6-oxo-4-phenyl-5-(4-phenyl-1,3-thiazol-2-yl)-1,6-dihydropyridine-3-carbonitrile has been obtained as main product by treatment of benzylidenemalononitrile with N-methyl-2-(1,3-thiazol-2-yl)acetamide. Dedicated to Professor I. Kalvinsh on his 60th birthday __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 777–781, May, 2007.