Harnessing Transition Metal Scaffolds for Targeted Antibacterial Therapy |
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Authors: | Dr Cheng Weng Dr Yong Leng Kelvin Tan Wayne Gareth Koh Prof Dr Wee Han Ang |
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Institution: | 1. Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544 Singapore;2. Hwa Chong Institution, 661 Bukit Timah Rd, Singapore, 269734 Singapore |
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Abstract: | Antimicrobial resistance, caused by persistent adaptation and growing resistance of pathogenic bacteria to overprescribed antibiotics, poses one of the most serious and urgent threats to global public health. The limited pipeline of experimental antibiotics in development further exacerbates this looming crisis and new drugs with alternative modes of action are needed to tackle evolving pathogenic adaptation. Transition metal complexes can replenish this diminishing stockpile of drug candidates by providing compounds with unique properties that are not easily accessible using pure organic scaffolds. We spotlight four emerging strategies to harness these unique properties to develop new targeted antibacterial agents. |
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Keywords: | Antimicrobial Resistance Biomimetics Bioorthogonal Catalysis Transition Metal Trojan Horse |
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