Spectrophotometric studies on the uranyl-ascorbate complex |
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| Affiliation: | 1. Cellbion Co., Ltd, Cancer Research Institute, Seoul National University, Jongno-gu, Seoul, Korea;2. Cardiovascular Research Institute, Yokohama City University, Graduate School of Medicine, Yokohama, Japan;3. Department of Materials Science and Engineering, NTNU, Norwegian University of Science and Technology, Trondheim, Norway;4. Okinawa Institute of Science and Technology Graduate University, Onna-son, Kunigami-gun, Okinawa, Japan;1. Belgian Nuclear Research Centre (SCK CEN), Institute for Nuclear Materials Science, Boeretang 200, Mol B-2400, Belgium;2. KU Leuven, Department of Chemistry, Celestijnenlaan 200F, P.O. Box 2404, B-3001 Heverlee, Belgium;3. ICSM, Univ Montpellier, CEA, CNRS, ENSCM, Bagnols-sur-Cèze, France;4. Forschungszentrum Jülich GmbH, Institute of Energy and Climate Research, IEK-6: Nuclear Waste Management and Reactor Safety, Jülich 52425, Germany;1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China;2. Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Science, 20 Dongdajie Street, Fengtai District, Beijing 100071, China;3. Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People''s Hospital, Shanghai 200233, China |
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| Abstract: | A systematic spectrophotometric study on the complexation of uranyl ions with ascorbic acid (vitamin C) is carried out. Factors influencing the sensitivity or selectivity of uranyl ascorbate are studied, and adequate elimination or control of the procedure is suggested. Results of the absorbance of uranyl ascorbate developed in HNO3, HCl, and H2SO4 acid media within the concentration range (1.0–8.0) × 10−N show a marked dependence on the nature and concentration of the acid used. The observed decrease in color intensity at higher acidities is explained on the basis of the decomposing effect of hydrogen ions on uranyl ascorbate and the complexing effect on uranyl ions. Study of the stoichiometry of uranium:ascorbic acid complex in acid medium by continuous variation and molar ratio methods indicated the formation of 1:1 and 1:2 complexes. The formation constant of the 1:1 complex as calculated by these two methods was found to be 4.8 × 104 and 5.0 × 104, respectively. Best suitable conditions for stabilizing and increasing the color intensity of uranyl ascorbate, dependent on the nature of the medium and pH of the solution, are suggested for the determination of ascorbic acid in pharmaceutical preparations using this method. |
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