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Apoptosis of supraoptic AVP neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats |
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| Authors: | Yihua Wang Cuiping Zhao Zhigang Wang Chengwei Wang Wenfeng Feng Lijin Huang Jialin Zhang Songtao Qi |
| Institution: | (1) Department of Neurosurgery, Nanfang Hospital of Nanfang Medical University, Guangzhou, 510515 Guangdong, PR China;(2) Department of Neurosurgery, Second Hospital of Shandong University, Jinan, 250033 Shandong, PR China;(3) Department of Neurology, Second Hospital of Shandong University, Jinan, 250033 Shandong, PR China |
| Abstract: | BackgroundIt has been reported that various types of axonal injury of hypothalamo-neurohypophyseal tract can result in degeneration of the magnocellular neurons (MCNs) in hypothalamus and development of central diabetes insipidus (CDI). However, the mechanism of the degeneration and death of MCNs after hypophysectomy in vivo is still unclear. This present study was aimed to disclose it and to figure out the dynamic change of central diabetes insipidus after hypophysectomy. |
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