Total syntheses of carbohydrates: organocatalyzed aldol additions of dihydroxyacetone |
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Authors: | Markert Morris Mahrwald Rainer |
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Institution: | Institut für Chemie, Humbold‐Universit?t, 12489 Berlin, Brook‐Taylor Strasse 2, Germany, Fax: (+49)?30‐2093‐5553 |
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Abstract: | The selective total synthesis of carbohydrates with defined configuration has been of great interest for a long time. This field has been the domain of enzymatic methods so far. But now the recent development of several organocatalyzed aldol methodologies has made a selective synthetic approach to configuratively defined carbohydrates possible. This development and different strategies will be discussed in this concept article. |
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Keywords: | aldol reaction aldolase base catalysis carbohydrates organocatalysis |
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