乙烯基桥联的8-羟基喹啉衍生物的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究

设计合成了2-乙烯基取代的8-羟基喹啉衍生物(6), 用IR, UV-Vis, 1H NMR, MS和元素分析确认其结构; 利用二苯代苦味酰基自由基(DPPH·)法和噻唑蓝比色(MTT)法分别测定了目标产物的抗氧化活性及调控鼠骨髓间质干细胞(MSCs)增殖的作用. 结果表明, 目标产物有较强的抗氧化活性, 随着产物浓度的增加, 其抗氧化活性先增强后减弱; 在低浓度时对鼠骨髓间质干细胞有促进作用. 研究发现, 化合物6抗氧化活性的提高与其含量相关.

Synthesis, Antioxidation Activity of Bridged Vinyl-8-hydroxyquinolin Derivative and Its Induction Proliferation of Mesenchymal Stem Cells

2-Vinyl-8-hydroxyquinolin derivative(6) was synthesized and characterized by IR, UV-Vis, ~1H NMR, MS and elemental analysis. Meanwhile, the title compound was biologically evaluated by the MTT assay on the proliferation the antioxidation activity. The results show that the title compound can induce the proliferation of mesenchymal stem cell compared with the control group under a low concentration condition and inhibitive effect on a higher concentration condition. The results also show that compound 6 has strong antioxidation activity. With concentration increasing, antioxidation activity is first increased and then decreased. It was found that the increasing antioxidant property of this protein depended quantitatively on the increase of its the compound 6 content.