A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin |
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| Authors: | Findley Thomas J K Sucunza David Miller Laura C Helm Matthew D Helliwell Madeleine Davies David T Procter David J |
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| Institution: | School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK. |
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| Abstract: | The cis-hydrindane motif is found in a number of natural products that display important biological activity. A flexible, stereoselective approach to the framework has been developed that features highly diastereoselective, SmI(2)-mediated cyclisations. The strategy has been exploited in the first synthesis of the proposed structure of faurinone and an approach to the skeleton of the antibacterial natural product, pleuromutilin. |
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