Organolithium-mediated conversion of beta-functionalised aziridines into alkynyl amino alcohols and diamines |
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| Authors: | Huang Jianhui O'Brien Peter |
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| Institution: | Department of Chemistry, University of York, Heslington, York, UK YO10 5DD. |
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| Abstract: | The direct conversion of dihydrofuran and dihydropyrrole N-triisopropylbenzenesulfonyl aziridines into alkynyl amino alcohols and diamines respectively can be achieved using 3 equiv. sec-butyllithium-PMDETA in THF; use of n-butyllithium and (-)-sparteine in Et2O gave an alkynyl amino alcohol in 60% ee. |
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