A chiral pyrrolidine-pyrazole catalyst for the enantioselective Michael addition of carbonyls to nitroolefins |
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| Authors: | Srivari Chandrasekhar Togapur Pavan KumarKothapalli Haribabu Chada Raji ReddyChitumalla Ramesh Kumar |
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| Affiliation: | a Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
b Inorganic and Physical Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | An enantioselective Michael reaction of carbonyl compounds to nitroolefins has been accomplished using a novel chiral pyrrolidine-pyrazole catalyst. This newly prepared catalyst was found to be very effective in providing good yields as well as good diastereo- and enantio-selectivities. The mechanism of the reaction has also been substantiated by mass spectral studies. |
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