Carbohydrate-derived alcohols as organocatalysts in enantioselective aldol reactions of isatins with ketones |
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| Authors: | Chao Shen Fangyi ShenHaijun Xia Pengfei Zhang Xinzhi Chen |
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| Affiliation: | a Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
b College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China |
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| Abstract: | The catalytic activity of carbohydrate-derived amino alcohols in the enantioselective aldol reaction of ketones with isatin and its derivatives has been examined for the first time. The carbohydrate-derived amino alcohols 5 were found to be efficient organocatalysts for asymmetric aldol reactions. A variety of isatins were used as substrates and the corresponding aldol products were obtained in high yields (up to 99%) and with moderate enantioselectivities (up to 75%). |
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