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 ,-Difluoroketone inhibitors of HMG CoA reductase |
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| Authors: | Geoffrey B Dreyer and Brian W Metcalf |
| Institution: | Department of Medicinal Chemistry, Smith Kline & French Laboratories 709 Swedeland Road, Swedeland, PA 19479, USA |
| Abstract: | The rationale for a new class of HMG CoA reductase inhibitors, represented by ,ga-difluoroketones 3 and 4, is described. The syntheses of 3, 4, and their nonfluorinated analogue 5 are presented. |
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