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Synthesis and characterization of water-soluble O-succinyl-chitosan |
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| Authors: | Can Zhang Qineng Ping Jian Shen |
| Affiliation: | a Research Center of Surface and Interface Chemistry and Engineering Technology, Nanjing University, No. 22, Hankou Road, Nanjing 210093, PR China b College of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China c Department of Applied Chemistry, Nanjing Normal University, Nanjing 210024, PR China |
| Abstract: | The efficient procedure to prepare novel water-soluble O-succinyl-chitosan was established by using one three-step reaction. Phthaloyl group was firstly chosen as the protection group for the amino group of chitosan, and O-succinylation was then completed. Protection group was removed finally by using hydrazine hydrate. The chemical structure of the modified chitosan was characterized by FTIR, 1H-NMR, 13C-NMR and elemental analysis. Some physical properties were analyzed by X-ray diffraction, differential scanning calorimetry (DSC), thermogravimetry (TG) and solubility test. It indicates that after O-succinylation, the modified chitosan shows much better solubility in water. The study of enzymatic degradation showed that the O-succinyl-chitosan was of low susceptibility to lysozyme. O-succinylation-chitosan is a useful intermediate, which permits further chemical modification for amino group and may be have potential applications in biomedical system. |
| Keywords: | Chitosan O-Succinyl-chitosan Water-soluble Characterization |
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