A general model for non-autocatalytic zymogen activation in the presence of two different and mutually exclusive inhibitors. I. Kinetic analysis |
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| Authors: | J. Masiá-Pérez J. Escribano E. Valero E. Arribas M. García-Moreno J. L. Muñoz-Muñoz R. Gómez-Ladrón de Guevara R. Varón |
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| Affiliation: | 1.Servicio de Cardiología, Complejo Hospitalario Universitario de Albacete,Albacete,Spain;2.Departamento de Ciencia y Tecnología Agroforestal y Genética,Universidad de Castilla-La Mancha,Albacete,Spain;3.Departamento de Química-Física,Universidad de Castilla-La Mancha, Escuela de Ingenieros Industriales de Albacete,Albacete,Spain;4.Departamento de Física Aplicada,Universidad de Castilla-La Mancha,Albacete,Spain;5.Departamento de Bioquímica y Biología Molecular A,Universidad de Murcia,Murcia,Spain |
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| Abstract: | The kinetic study carried out in paper I of this series (preceding article) on enzyme systems involving zymogen activation and the simultaneous action of two different, mutually exclusive inhibitors (Scheme 1) allows, new dimensionless kinetic parameters to be suggested. These parameters furnish quantitative information about the relative weight of the activation and inhibition routes, i.e. the conditions under which the activation prevails over the inhibition and vice versa, as well as the absolute and relative contributions to overall inhibition of each of the inhibition routes and their synergistic effect. These results can be easily and directly applied to any of the thousands of particular cases of the model. Examples are given for different particular cases. |
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