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系统指纹定量法鉴别龙胆泻肝丸质量
引用本文:孙国祥,张静娴. 系统指纹定量法鉴别龙胆泻肝丸质量[J]. 分析化学, 2009, 37(8)
作者姓名:孙国祥  张静娴
作者单位:沈阳药科大学药学院,沈阳,110016
基金项目:国家自然科学基金重大研究计划课题 
摘    要:建立龙胆泻肝丸(Longdanxiegan pill,LDXGP)的高效液相色谱(HPLC)指纹图谱,以系统指纹定量法评价其质量.采用RP-HPLC法,以宏定性相似度为参量对12批LDXGP进行聚类分析,确定用其中10批生成对照指纹图谱(RFP),以此RFP为标准用系统指纹定量法评价12批LDXGP质量.以龙胆苦苷为参照物峰,确定60个共有指纹峰,建立了LDXGP的HPLC指纹图谱.用系统指纹定量法鉴别出8批质量合格,1批含量明显偏高,1批含量明显偏低,2批化学成分数量和分布比例不合格.系统指纹定量法将整体定性分析和整体定量分析密切结合,是评价中药质量的有效方法.

关 键 词:系统指纹定量法  龙胆泻肝丸  高效液相色谱指纹图谱  宏定性相似度  宏定量相似度  相对信息量指数

Evaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method
SUN Guo-Xiang,ZHANG Jing-Xian. Evaluating Authentic Quality of Longdanxiegn Pill by Systematic Quantified Fingerprint Method[J]. Chinese Journal of Analytical Chemistry, 2009, 37(8)
Authors:SUN Guo-Xiang  ZHANG Jing-Xian
Affiliation:SUN Guo-Xiang,ZHANG Jing-Xian(College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016)
Abstract:Using systematic quantified fingerprint method to assess the HPLC fingerprint of Longdanxiegan pill(LDXGP),in which the chromatographic fingerprints(CFPs)were determined by reversed-phase HPLC.The 12 batches of LDXGP were identified with hierarchical clustering analysis by using micro qualitative similarity as the variable.According to the results of classification,the referential fingerprint(RFP)was synthesized from 10 batches of LDXGP.Taking the RFP for the qualified model,the whole 12 batches of LDXGP we...
Keywords:Systematic quantified fingerprint method  Longdanxiegen pill  high performance liquid chromatography fingerprint  macro qualitative similarity  macro quantitative similarity  chromatographic fingerprint relative informative index  
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