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A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target |
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| Authors: | Wakata Aya Cahill Sean M Blumenstein Michael Gunby Rosalind H Jockusch Steffen Marti Angel A Cimbro Barbara Gambacorti-Passerini Carlo Donella-Deana Arianna Pinna Lorenzo A Turro Nicholas J Lawrence David S |
| Affiliation: | Department of Biochemistry, The Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA. |
| Abstract: | A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase. |
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