Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing |
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| Authors: | Itaka Keiji Kanayama Naoki Nishiyama Nobuhiro Jang Woo-Dong Yamasaki Yuichi Nakamura Kozo Kawaguchi Hiroshi Kataoka Kazunori |
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| Affiliation: | Department of Materials Science and Engineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. |
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| Abstract: | An siRNA nanocarrier formed through self-assembly of PEG-based block catiomer possessing two distinct amino groups with different pKa values in a side chain was developed. This design provided the carrier with a sufficient siRNA complexation and an assumed buffering capacity in the endosomes, allowing it to exhibit remarkable gene knockdown abilities as well as sufficient serum tolerability. |
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