Concise,asymmetric total synthesis of spirotryprostatin A |
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Authors: | Onishi Tomoyuki Sebahar Paul R Williams Robert M |
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Institution: | Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA. |
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Abstract: | structure: see text] The structurally intriguing cell-cycle inhibitor spirotryprostatin A has been synthesized utilizing an azomethine ylide dipolar cycloaddition reaction as the key step. This pentacyclic alkaloid contains a prenylated tryptophan-derived oxindole moiety that has been created in a regiocontrolled and stereocontrolled manner in a single step. |
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