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The Synthesis,Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid
Authors:Jie Zhang  Tingting Jiang  Xinyu Song  Qing Li  Yang Liu  Yanhua Wang  Xiaoyan Chi  Jie Sun  Liangliang Zhang
Affiliation:1.School of Life Science, Ludong University, Yantai 264025, China;2.Ningbo Institute of Northwestern Polytechnical University, Northwestern Polytechnical University (NPU), Ningbo 315103, China
Abstract:A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu2(L)2·2NMP}n (H2L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration.
Keywords:copper, flavone-6,2′  -dicarboxylic acid, crystal structure, anti-tumor activity
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