| 2-(2-苯并噁唑啉酮-3-甲基)-6-芳基-咪唑[2,1-b][1,3,4]噻二唑的NMR谱研究 |
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| 引用本文： | 李英俊,李春燕,靳焜,安静,王雷雷,赵星. 2-(2-苯并噁唑啉酮-3-甲基)-6-芳基-咪唑[2,1-b][1,3,4]噻二唑的NMR谱研究[J]. 波谱学杂志, 2010, 27(4): 617-622. DOI: 10.3969/j.issn.1000-4556.2010.04.012 |
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| 作者姓名： | 李英俊 李春燕 靳焜 安静 王雷雷 赵星 |
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| 作者单位： | 辽宁师范大学 化学化工学院，辽宁 大连 116029 |
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| 基金项目： | Natural Science Foundation of Liaoning Province (20102126) and Education office Foundation of Liaoning Province (2008345) |
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| 摘 要： | 许多文献已报道，含有咪唑[2,1-b][1,3,4]噻唑环的衍生物具有抗癌、抗结核、抗菌、抗真菌、抗惊厥、止痛等活性. 该文合成了一个新的在医药方面具有潜在应用价值的咪唑[2,1-b][1,3,4]噻二唑衍生物，即2-(2-苯噁唑啉酮-3-甲基)-6-苯基-咪唑[2,1-b][1,3,4]噻二唑，并利用2D NMR技术对其1H NMR 和13C NMR谱进行了全归属.
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| 关 键 词： | 核磁共振（NMR) 归属 2D NMR 2-苯并噁唑啉酮 咪唑[2 1-b][1 3 4]噻二唑 |
| 收稿时间： | 2010-01-18 |
An NMR Study on 2-[(2-Benzoxazolinone-3-yl)methyl]-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole |
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| LI Ying-jun,LI Chun-yan,JIN Kun,AN Jing,WANG Lei-lei,ZHAO Xing. An NMR Study on 2-[(2-Benzoxazolinone-3-yl)methyl]-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole[J]. Chinese Journal of Magnetic Resonance, 2010, 27(4): 617-622. DOI: 10.3969/j.issn.1000-4556.2010.04.012 |
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| Authors: | LI Ying-jun LI Chun-yan JIN Kun AN Jing WANG Lei-lei ZHAO Xing |
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| Affiliation: | College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China |
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| Abstract: | Many compounds containing imidazo[2,1-b][1,3,4]thiadiazole ring showed pharmacological properties such as anticancer, antitubercular, antibacterial, antifungal, anticonvulsant, analgesic activities.In this paper, a novel compound which may have potential pharmaceutical applications, 2-[(2-benzoxazolinone-3-yl)methyl]-6-phenyl-imidazo[2,1-b][1,3,4] thiadiazole, was synthesized.Its 1 H and 13C NMR chemical shifts were assigned using 2D NMR techniques, including gHMQC, gHMBC and 1 H-1 H COSY. |
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| Keywords: | NMR assignment 2D NMR 2-benzoxazolinone imidazo[2,1-b][1,3,4]thiadiazole |
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