Inherently chiral calixarenes

Due to the nonplanarity of the basic 1_n-metacyclophane system, calixarenes and resorcarenes can be transformed into molecules with inherent chirality. Various attempts to achieve this goal are reviewed. Special emphasis is given to derivatives withC_n-symmetry, including derivatives of spherand calixarenes and other calixarene-like macrocycles.This paper is dedicated to the commemorative issue on the 50th anniversary of calixarenes.