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4-Chloro-3-(trifluoroacetyl)coumarin as a novel building block for the synthesis of 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones |
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| Authors: | Viktor O Iaroshenko Sajid AliTariq Mahmood Babar Sergii DudkinSatenik Mkrtchyan Nasim Hasan RamaAlexander Villinger Peter Langer |
| Institution: | a Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany b National Taras Shevchenko University, 62 Volodymyrska st., Kyiv-33, 01033, Ukraine c Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan d Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany |
| Abstract: | 4-Chloro-3-(trifluoroacetyl)coumarin was synthesized for the first time via direct TMSCl-mediated acylation of 4-hydroxycoumarin with TFAA followed by the treatment with POCl3. The reaction of 4-chloro-3-(trifluoroacetyl)coumarin with commercially available anilines is a two-step method, which affords a set of 7-(trifluoromethyl)-6H-chromeno4,3-b]quinolin-6-ones in good to excellent yields. |
| Keywords: | Cyclization Coumarins Anilines Heterocycles Fluorine Chromeno[4 3-b]quinolines |
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