Separation and identification of steroidal compounds with cytotoxic activity against human gastric cancer cell lines in vitro from the rhizomes of Paris polyphylla var. chinensis |
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Authors: | Huang Yun Cui Lijian Zhan Wenhong Dou Yuhong Wang Yongli Wang Qiang Zhao Ding |
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Affiliation: | (1) Department of Pharmacognosy, Pharmaceutical College, Hebei Medical University, 050017, China;(2) Chinese Traditional Medicine College, Hebei Medical University, 050019, China;(3) China Pharmaceutical University, 210038, China |
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Abstract: | A novel steroidal saponin, along with 12 known steroidal compounds, was isolated from the rhizomes of Paris polyphylla var. chinensis. Spectral data, including two-dimensional NMR, showed that the structure of the novel saponin was 3β,21-dihydroxypregnane-5-en-20S-(22,16)-lactone-1-O-α-L-rhamnopyranosyl(1→2)-[β-D-xylopyranosyl(1→3)]-β-D-glucopyranoside. The isolated steroidal compounds were evaluated for their cytotoxic activity on human gastric cancer cell line HepG2, SGC7901, BxPC3. Diosgenin-3-O-α-L-rhamnopyranosyl(1→2)[α-L-rabinofuranosyl(1→4)]-β-D-glucopyranoside exhibited the most potent cytotoxic activity among the isolated steroids. Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 556–560, November–December, 2007. |
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Keywords: | Paris polyphylla var. chinensis Paris steroidal compound cytotoxic activity human gastric cancer cell line HepG2 SGC7901 BxPC3 |
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