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Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes
Authors:Campbell Craig D  Duguet Nicolas  Gallagher Katherine A  Thomson Jennifer E  Lindsay Anita G  O'Donoghue Annmarie C  Smith Andrew D
Institution:EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, UK KY16 9ST.
Abstract:Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (+/-)-4-phenoxycarbonylazlactones in good isolated yields (66-84%) from the corresponding N-p-anisoyl amino acids.
Keywords:
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