Multicomponent reactions are accelerated in water |
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Authors: | Pirrung Michael C Sarma Koushik Das |
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Affiliation: | Department of Chemistry, Levine Science Research Center, Duke University, Durham, North Carolina, 27708, USA. michael.pirrung@duke.edu |
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Abstract: | Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct isolation by precipitation. The methods were applied to the preparation of three small combinatorial libraries. |
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