Benzyl protection of phenols under neutral conditions: palladium-catalyzed benzylations of phenols. |
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| Authors: | Ryoichi Kuwano Hiroki Kusano |
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| Institution: | Department of Chemistry, Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. rkuwano@chem.kyushu-univ.jp |
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| Abstract: | Benzyl protection of phenols under neutral conditions was achieved by using a Pd(eta3-C3H5)Cp-DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded in the presence of the catalyst, yielding aryl benzyl ethers. |
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