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Synthesis and antitumor activity of 7-azaindirubin |
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| Authors: | Zhao Hui Wanga Wen Yun Lib Fu Long Lib Lei Zhangb Wei Yi Huab Jing Cai Chengc Qi Zheng Yao a |
| Affiliation: | a Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China;b School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;c Wuxi JC Pharmaceutical Technology Inc., Wuxi 214036, China |
| Abstract: | Twenty 7-azaindirubin derivatives were designed and synthesized.Their antitumor activities were evaluated in vitro against DU145 cell line.The pharmacological results showed that most of the prepared compounds displayed the excellent activity.Compound 18 exhibited the most potent antitumor activity among the tested compounds. |
| Keywords: | 7-Azaindirubin Synthesis Antitumor activity |
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