Simple diastereoselectivity on addition of alpha-haloalkyl Grignard reagents to benzaldehyde |
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| Authors: | Schulze Volker Nell Peter G Burton Andrew Hoffmann Reinhard W |
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| Affiliation: | Fachbereich Chemie der Philipps-Universit?t Marburg, Hans Meerwein Str., Germany. |
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| Abstract: | The addition of alpha-haloalkyl Grignard reagents to benzaldehyde occurs with simple diastereoselectivity substantially higher than that of the corresponding lithium reagents. Reaction in the presence of dimethyl-aluminum chloride suppresses subsequent Oppenauer oxidation of the resulting Mg-alkoxides by excess benzaldehyde. |
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