Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2'-amino-LNA monomers |
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| Authors: | Sørensen Mads D Petersen Michael Wengel Jesper |
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| Affiliation: | Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark. |
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| Abstract: | A molecular dynamics (MD) simulation, synthesis and very efficient hybridization for a series of N-acylated and N-alkylated derivatives of 2'-amino-LNA are reported. |
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