| 盐酸雷尼替丁的共振光散射新体系研究及其分析应用 |
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| 引用本文： | 冯素玲,吴呈珂,曾超.盐酸雷尼替丁的共振光散射新体系研究及其分析应用[J].分析试验室,2009,28(4). |
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| 作者姓名： | 冯素玲 吴呈珂 曾超 |
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| 作者单位： | 河南师范大学化学与环境科学学院,新乡,453007 |
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| 基金项目： | 河南省新乡市科技发展 |
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| 摘 要： | 在酸性条件下,盐酸雷尼替丁、铬黑T和钼酸铵通过静电作用形成三元离子缔合物,使体系的共振光散射明显增强.据此建立了共振光散射测定盐酸雷尼替丁的新方法.在最佳条件下,体系的最大散射峰位于363 nm处.共振光散射增强的程度与盐酸雷尼替丁的浓度呈良好的线性关系.方法的线性范围在0.015～0.165 mg/mL,检出限为9.5×10-3 mg/mL.将该方法用于市售盐酸雷尼替丁片的测定,并与药典方法进行对照,证明两种方法之间无显著性差异.
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| 关 键 词： | 盐酸雷尼替丁 钼酸铵 铬黑T 共振光散射 |
Study on system of ranitidine hydrochloride by resonance light scattering and its analytical application |
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| FENG Su-ling,WU Cheng-ke,ZENG Chao.Study on system of ranitidine hydrochloride by resonance light scattering and its analytical application[J].Chinese Journal of Analysis Laboratory,2009,28(4). |
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| Authors: | FENG Su-ling WU Cheng-ke ZENG Chao |
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| Institution: | College of Chemistry and Environmental Science;Henan Normal University;Xinxiang 453007 |
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| Abstract: | Ranitidine hydrochloride,eriochrome black T and ammonium molybdate form a ternary association complex by virtue of electrostatic attraction in acidic media,which results in the significant enhancement of resonance light scattering(RLS) intensity.Based on this,a new method was established to determine ranitidine hydrochloride.The maximum scattering peak of the system is located at 363 nm.Under optimal conditions,the enhanced intensity of RLS is proportional to the concentrations of ranitidine hydrochloride i... |
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| Keywords: | Ranitidine hydrochloride Ammonium molybdate Eriochrome black T Resonance light scattering |
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