季铵盐、季膦盐类高分子抗菌剂的研究进展

综述了季铵盐、季膦盐类高分子抗菌剂的研究进展,包括该类抗菌剂的合成、性能及抗菌机理。现有的研究结果表明,含有多种杀菌基团高分子抗菌剂的抗菌作用可能与杀菌基团的种类、杀菌基团的固载量、载体与杀菌基的结合位置、杀菌基团的分布、载体的表面亲水性能、聚合物的交联度、链结构等有关。若能在分子结构中同时有序引入季铵盐或季膦盐、海因类杀菌基团,有可能存在杀菌基团的协同效应,并且可能形成一个新的高分子抗菌材料的研究分支。

Research Progress on Macromolecule Antimicrobial Agents of Quaternary Ammonium Salt and Season Phosphonic Salt

The macromolecule antibacterial agents of quaternary ammonium salt and season phosphonic salt were discussed, with emphasis on the synthesis, the performance and the antibacterium mechanics of macromolecule antibacterial agents. As the existing results showed, the effect of anti-bacterial containing a variety of sterilization groups might be related to the type of sterilization groups, the solid capacity of sterilization groups, the combination position of the carrier and sterilization groups, the distribution of sterilization groups, the hydrophilicity of carrier, the crosslinking degree of polymer and chain structure. The paper presented if quaternary ammonium salt, season phosphonic salt and hydantoin sterilization groups were inserted orderly in molecular structure mutually, the cooperativity of sterilization groups could be happened and a new branch of macromolecule antimicrobial material might emerge.