| Purification and in vitro Activity of an Antimicrobial Peptide from Skin of Rana Temporaria Chensinensis, David |
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| 引用本文： | ZHOU Jie MENG Qing-fan XU Xue-song TIAN Xiao-le JIANG Fu-jia LI Qing-shan TENG Li-rong. Purification and in vitro Activity of an Antimicrobial Peptide from Skin of Rana Temporaria Chensinensis, David[J]. 高等学校化学研究, 2007, 23(4): 433-436. DOI: 10.1016/S1005-9040(07)60094-4 |
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| 作者姓名： | ZHOU Jie MENG Qing-fan XU Xue-song TIAN Xiao-le JIANG Fu-jia LI Qing-shan TENG Li-rong |
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| 作者单位： | ZHOU Jie1，MENG Qing-fan1，XU Xue-song2，TIAN Xiao-le1，JIANG Fu-jia1，LI Qing-shan1 and TENG Li-rong11.College of Life Science，Jilin University，Changchun 130012，P.R.China;2.Department of Laboratory，China-Japan Union Hospital，Jilin University，Changchun 130033，P.R.China |
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| 摘 要： | In this study,an antimicrobial component(RTCI)was purified from the skin of Rana temporaria chensinensis,David.Antimicrobial activities of RTCI against clinical multi-drug resistant bacterial strains,including Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureaus,Klebsiella oxytoca,Klebsiella pneumoniae,Enterococcus faecalis,and Proteus mirabilis were measured in vitro by means of minimal inhibitory concentration and time-kill studies.The results indicate that RTCI could inhibit the growth of these bacteria at a proper concentration and suggest that RTCI shows a better antimicrobial activity to Gram-negative bacterial strains than to Gram-positive bacterial strains.
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| 关 键 词： | 抗菌肽 多药抗性 动物皮肤 净化 体外活性 |
| 收稿时间： | 2006-09-11 |
Purification and in vitro Activity of an Antimicrobial Peptide from Skin of Rana Temporaria Chensinensis, David |
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| ZHOU Jie,MENG Qing-fan,XU Xue-song,TIAN Xiao-le,JIANG Fu-jia,LI Qing-shan,TENG Li-rong. Purification and in vitro Activity of an Antimicrobial Peptide from Skin of Rana Temporaria Chensinensis, David[J]. Chemical Research in Chinese University, 2007, 23(4): 433-436. DOI: 10.1016/S1005-9040(07)60094-4 |
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| Authors: | ZHOU Jie MENG Qing-fan XU Xue-song TIAN Xiao-le JIANG Fu-jia LI Qing-shan TENG Li-rong |
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| Affiliation: | 1. College of Life Science, Jilin University, Changchun 130012, P. R. China;2. Department of Laboratory, China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China |
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| Abstract: | In this study, an antimicrobial component (RTCI) was purified from the skin of Rana temporaria chensinensis,David. Antimicrobial activities of RTCI against clinical multi-drug resistant bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureaus, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis, and Proteus mirabilis were measured in vitro by means of minimal inhibitory concentration and time-kill studies.The results indicate that RTCI could inhibit the growth of these bacteria at a proper concentration and suggest that RTCI shows a better antimicrobial activity to Gram-negative bacterial strains than to Gram-positive bacterial strains. |
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| Keywords: | Antimicrobial peptides Multi-drug resistant Amphibian skin |
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