| Synthesis of New Ligand 1,2-Bis{di[（R,R）-1,3,2-oxzaphosphlidine]phosphino}ethane with C_2-symmetric Axis and Application in Rh-catalyzed Asymmetric Hydrogenation |
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| 作者姓名： | GONG Da-chun ZHOU Hua WEI Ping OUYANG Ping-kai |
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| 作者单位： | [1]College of Chemistry and Life Science, China Three Gorges University, Yichang 443001, P. R. China [2]College of Life Science and Pharmacy, Nanfing University of Technology, Nanfing 210009, P. R. China |
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| 基金项目： | Supported by the National Basic Research Program of China（ No. 2003CB716000） We are very grateful to Prof. ZHANG Sheng-yong from the Fourth Military Medical University for helpful discussions. |
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| 摘 要： | New ligand 1,2-bis{di（R,R）-1,3,2-oxzaphosphlidine]phosphino}ethane （R,R）-BDOPPEs 1,2,3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols.Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99%e.e.and 98%e.e.,respectively.This new class of（R,R）-BDOPPEs 1,2,3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.
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| 关 键 词： | 合成 C2对称 不对称催化加氢 亚膦基 乙烷 |
| 收稿时间： | 21 October 2006 |
| 修稿时间： | 2006-10-21 |
Synthesis of New Ligand 1,2-Bis { di[(R,R) -1,3,2-oxzaphosphlidine] phosphino} ethane with C2 -symmetric Axis and Application in Rh-catalyzed Asymmetric Hydrogenation |
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| GONG Da-chun ZHOU Hua WEI Ping OUYANG Ping-kai.Synthesis of New Ligand 1,2-Bis { di[(R,R) -1,3,2-oxzaphosphlidine] phosphino} ethane with C2 -symmetric Axis and Application in Rh-catalyzed Asymmetric Hydrogenation[J].Chemical Research in Chinese University,2007,23(5):544-548. |
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| Authors: | Da-chun GONG Hua ZHOU Ping WEI Ping-kai OUYANG |
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| Institution: | aCollege of Chemistry and Life Science, China Three Gorges University, Yichang 443001, P. R. China;bCollege of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 210009, P. R. China |
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| Abstract: | New ligand 1,2-bis{ di(R,R)-1,3,2-oxzaphosphlidine ] phosphino } ethane (R, R)-BDOPPEs 1, 2, 3 and 4 ] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino alcohols. Rh complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99% e. e. and 98% e. e. , respectively.This new class of (R,R)-BDOPPEs 1, 2, 3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite. |
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| Keywords: | (R R) -BDOPPE C2-Symmetry Asymmetric catalytic hydrogenation |
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